The Lowry houses two main theatres and studio space for performing arts (1,730, 466 and 180 seats respectively) presenting a full range of drama, opera, ballet, dance, musicals, children's shows, popular music, jazz, folk and comedy and gallery spaces (1,610 metres of floor space); showing the works of LS Lowry alongside contemporary exhibitions.

Movement into and through the building generates an air of theatricality, festivity and anticipation. The layout of The Lowry encourages visitors to explore and enjoy the variety of facilities housed within it, throughout the day and evening. An open ramped route with dramatic views connects the theatre foyers and gallery spaces, forming a public promenade around the building, linking all activities.